According to Entertainment Weekly, who's usually one of the more reliable sources out there, Marvel and ABC are considering a spinoff to their recently-popular series Agents of Shield, from Executive Producer Jeffrey Bell (Angel, X-files) and SHIELD writer Paul Zbyszewski, who also worked on Lost and Hawaii 5-0. There's no word yet on what the spinoff might entail, only that it would spin off of "certain ideas and themes" from this season of SHIELD. Rampant speculation is, of course, ill advised, and there's no guarantee this is even happening.
With that out of the way, let's get to rampantly speculating.
The major "theme" of this season, so far, is the introduction of the Inhumans to the MCU. So far, the show has avoided showing any parts of the Inhuman mythology that might show up in an eventual movie, except for brief hints of Attilan, their capital city. They've instead chosen to make these "gifted" individuals more of an analogue to the X-men - something that Marvel has been doing in recent years in order to stave off Fox's stranglehold on the X-men movie and TV rights. So if that's the big theme of this season, and we want to do a spinoff, I'm gonna go ahead and speculate hard that this will be about a team of superpowered individuals. Maybe SHIELD sponsored, maybe rogues - in fact, rogues would be better, as they could then come into conflict with SHIELD on the weekly crossovers.
While I doubt they'd move Skye over to another show permanently, there are a few characters, like Raina and Eyeless-Guy, who would fit perfectly into a demographic like that, and it would satisfy the itch to have an X-men-like show on TV.
